Persistent Chiral Step-Defect of the Chrysene Lattice: Homochirality of Amino Acids, Sugars, and Membrane Lipids, and Consistency with the Meteoritic Record

Abstract

iological homochirality—L-amino acids, D-sugars, and the specific stereochemistry of membrane lipids—remains unexplained by unconstrained stochastic chemistry. Carbonaceous chondrites preserve the only known pre-terrestrial enantiomeric excesses of matching sense (L-excesses in α-methyl amino acids, D-excesses in aldonic acids) together with indigenous chrysene-family polycyclic aromatic hydrocarbons.

Under the Identification Hypothesis the tetrasubstituted chrysene lattice carries a native chiral step-defect. Patent US 12,195,423 already maps this defect into paired nucleobases and, via the catalyst chrysene, into the membrane component. The same defect, constrained by the C12 tether geometry of the dual-cage synthesis, produces a statistical excess of L-amino acids. Controlled bay scission generates a void complementary to D-fructose; the stereochemistry fixed at this stage is retained through the glycolytic metabolon into glucose and related sugars. The identical stereochemical packet persists from the dual-chrysene catalyst through hopanoids and sterols into membrane-bound cholesterol.

A single geometric object therefore accounts for the handedness of the three major biopolymer classes and is consistent with the meteoritic record in which the chrysene skeleton and the enantiomeric excesses of biological sense coexist. Homochirality is framed as the biological amplification of a persistent lattice bias that was already available in the prebiotic and extraterrestrial organic inventory.